CDC released the FY2025 ICD-10-CM with 252 new codes, 36 code deletions, and 13 code revisions making the cut, going into effect on October 1, 2024.

Key Features:

• Index of Drugs and Chemicals
• Index of Diseases and Injuries
• Index of External Causes of Injuries
• Index of Neoplasm
• The National Center for Health Statistics (NCHS) and the Centers for Medicare and Medicaid Services are the U.S. governmental agencies responsible for overseeing all changes and modifications to the ICD-10-CM.

Highlights from the new 2025 ICD-10-CM codes
ICD-10 codes for cancer in remission
The neoplasm chapter contains codes for most benign and all malignant neoplasms.
Chapter 2 - Neoplasms leads the way this year in the quantity of new codes, receiving .63 new codes expanding cancer to include "in remission."

• C81.1A Nodular sclerosis Hodgkin lymphoma, in remission
• C81.2A Mixed cellularity Hodgkin lymphoma, in remission
• C81.3A Lymphocyte depleted Hodgkin lymphoma, in remission
• C82.5A Diffuse follicle center lymphoma, in remission
• C82.6A Cutaneous follicle center lymphoma, in remission

Updates to ICD-10 codes for Hypolycemia and Obesity
Chapter 4 – Endocrine, nutritional and metabolic diseases adds level and class to Hypolycemia and Obesity.

• E16.A2 Hypoglycemia level 2
• E16.A3 Hypoglycemia level 3
• E66.81 Obesity class
• E66.811 Obesity, class 1
• E74.82 Disorders of citrate metabolism
• E74.820 SLC13A5 Citrate Transporter Disorder
• E74.829 Other disorders of citrate metabolism

ICD-10 codes for mental health disorders
In the 2025 update of ICD-10-CM,
Chapter 5 – Mental and Behavioral Disorders adds type and severity to eating disorders and 2 new codes for mental and behavioral conditions in adults.

• F50.010 Anorexia nervosa, restricting type, mildF50.023 Anorexia nervosa, binge eating/purging type, extreme
• F50.21 Bulimia nervosa, mild
• F50.814 Binge eating disorder, in remission
• F50.83 Pica in adults
• F50.84 Rumination disorder in adults

Updated ICD-10 codes for diseases of the digestive system
Chapter 11 – Diseases of the Digestive System adds fifth and sixth character codes for conditions for 2025, providing additional details on the complexity of the condition.

• K60.311 Anal fistula, simple, initial
• K60.32 Anal fistula, complex
• K60.413 Rectal fistula, simple, recurrent
• K60.422 Rectal fistula, complex, persistent
• K60.50 Anorectal fistula, unspecified
• K60.519 Anorectal fistula, simple, unspecified
• K60.522 Anorectal fistula, complex, persistent

ICD-10 codes for conditions affecting bones, joints, or muscles
In another example of adding specificity,
Chapter 13 – Diseases of the Musculoskeletal System and Connective Tissue bulks up synovitis and tenosynovitis by adding information for specific locations.

• M65.971 Unspecified synovitis and tenosynovitis, right ankle and foot
• M65.972 Unspecified synovitis and tenosynovitis, left ankle and foot
• M65.979 Unspecified synovitis and tenosynovitis, unspecified ankle and foot
• M65.98 Unspecified synovitis and tenosynovitis, other site
• M65.99 Unspecified synovitis and tenosynovitis, multiple sites