Skyscape Web Viewer : TNM Cancer Staging System : Main Index

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International Thymic Malignancies Interest Group (ITMIG)
In the context of oropharyngeal cancer, the optimal cut-off for p16 overexpression as a surrogate HR HPV biomarker is greater than or equal to +2/+3 nuclear staining intensity (+/- cytoplasmic staining) with greater than or equal to 75% distribution
T1 is defined as tumor 5 cm in greatest dimension, no extra-adrenal invasion
T1 is defined as tumor with a maximum clinical diameter 2 cm
T1 is tumor confined to uterus
T1 is tumor confined to vagina
T1-T3 as defined in Definition of Primary Tumor (T)
T1 tumor of the hypopharynx with involvement of the post-cricoid area
T1 tumor of the hypopharynx with involvement of the posterior wall
T1 tumor of the hypopharynx with involvement of the pyriform sinus
T1 tumors may involve either the parietal pleura alone (left) or the parietal and visceral pleura (right)
T1 tumors of the glottis are limited to the vocal cord(s) with normal mobility (may involve anterior or posterior commissure)
T1 tumors of the oropharynx are 2 cm or smaller in greatest dimension
T1 tumors of the subglottis are limited to the subglottis
T2a: Tumor larger than 7 cm in greatest dimension, but not larger than 10 cm, limited to the kidney
T2a2 is clinically visible lesion more than 4
T2a is tumor without parametrial invasion
T2a melanoma
T2 and T3 tumors with urethral invasion
T2b: Tumor larger than 10 cm in greatest dimension
T2b for leiomyosarcoma, endometrial stromal sarcoma, and adenosarcoma is tumor involving other pelvic tissues
T2b is tumor with parametrial invasion
T2b melanoma
T2 for leiomyosarcoma, endometrial stromal sarcoma, and adenosarcoma is tumor extending beyond the uterus, within the pelvis
T2 for the supraglottis is defined as tumor invading the mucosa of more than one adjacent subsite of supraglottis or glottis or region outside the supraglottis (e
T2 for the supraglottis with invasion of ventricular bands (false cords) and the epiglottis
T2 in the nasal cavity and ethmoid sinus is defined as invading two subsites in a single region or extending to involve an adjacent region within the nasoethmoidal complex, here the nasal cavity, with or without bony invasion
T2 involves each of the ipsilateral pleural surfaces (parietal, mediastinal, diaphragmatic, and visceral pleura) with at least one of the following: involvement of diaphragmatic muscle (as illustrated) and/or extension of tumor from the visceral pleura into the underlying pulmonary parenchyma (as illustrated)
T2 is defined as a tumor larger than 2 cm but not larger than 4 cm in greatest dimension
T2 is defined as tumor 5 cm, no extra-adrenal invasion