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Targeted Cancer Therapy A Handbook for Nurses
Chapter 2. Targeted Cancer Therapy: External and Internal Signaling Pathway Targets
Table of Contents
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About
Application Of The Hallmarks Of Cancer
Bone Metastasis
Encouraging Patient Adherence and Persistence
Epigenetic Abnormalities (Dna Methyltransferase and Histone Deacetylase)
Epigenetics
Hypoxia-Inducible Factor, Mtor, and Angiogenesis
Intracellular Signaling Kinases (E.g., Src, P13k/Akt/Mtor; Mapk; Sonic Hedgehog Pathways)
Introduction
Protein Dynamics: Heat Shock Proteins and Ubiquitin - Proteasome Inhibitors
Protein Kinase Inhibitors
Targeting Angiogenesis
Chapter 1. Cancer Biology, Signaling Pathways, and Malignant Transformation
Application Of The Hallmarks Of Cancer
Chapter 1. Cancer Biology, Signaling Pathways, and Malignant Transformation
Epigenetics
Hallmarks Of Cancer
Invasion and Metastasis
References
Summary
Chapter 2. Targeted Cancer Therapy: External and Internal Signaling Pathway Targets
Chapter 2. Targeted Cancer Therapy: External and Internal Signaling Pathway Targets
Epigenetic Abnormalities (Dna Methyltransferase and Histone Deacetylase)
Hepatocyte Growth Factor (Hgf/C-Met) Receptor Pathway Targets
Insulin-Like Growth Factor Receptor Pathway Targets
Intracellular Signaling Kinases (E.g., Src, P13k/Akt/Mtor; Mapk; Sonic Hedgehog Pathways)
Membrane-Bound Receptor Kinases (E.g., Egfr, Her2, Hgf/C-Met, Igfr Pathways)
Monoclonal Antibodies
Protein Dynamics: Heat Shock Proteins and Ubiquitin - Proteasome Inhibitors
Protein Kinase Inhibitors
Protein Kinase Signaling Pathways
References (Chapter 2)
Tumor Vasculature and Microenvironment
Chapter 3. Tumor Vasculature
Antiangiogenic Drug Therapy
Hypoxia-Inducible Factor, Mtor, and Angiogenesis
Nursing Considerations and Drug Information
References (Chapter 3)
Targeting Angiogenesis
Chapter 4. Targeting the Microenvironment: Bone Metastasis, Apoptosis, DNA Repair, and Mitosis
Bone Metastasis
Dna Repair Gene Mutations: Opportunities From Synthetic Lethality
Mitotic Kinase Inhibitors
Pharmacologic Management
References (Chapter 4)
Summary (Chapter 4)
Targeting Apoptosis
Chapter 5. Challenges in Caring for Patients Receiving Targeted Therapy
Drug Interactions: Focus On The P450 Microenzyme System
Encouraging Patient Adherence and Persistence
References (Chapter 5)
Glossary
Glossary
Front Matter
Introduction
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