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Section 1. Care of the Hospitalized Patient
- 1. Electrolytes
- 10. Palliative and End-of-Life Care
- 2. Acid-Base Disorders
- 3. Diagnostic Imaging in Internal Medicine
- 4. Procedures Commonly Performed by Internists
- 5. Principles of Critical Care Medicine
  - 5. Principles of Critical Care Medicine
  - F - 5-1. Approach to Pt in Shock
- 6. Pain and Its Management
- 7. Assessment of Nutritional Status
- 8. Enteral and Parenteral Nutrition
- 9. Transfusion and Pheresis Therapy
- Section 1. Care of the Hospitalized Patient
Section 2. Medical Emergencies
- 11. Cardiovascular Collapse and Sudden Death
- 12. Shock
- 13. Narcotic Overdose
  - 13. Narcotic Overdose
  - T - 13-1. Management of Opioid Overdose
- 14. Sepsis and Septic Shock
  - 14. Sepsis and Septic Shock
  - T - 14-1. Initial Antimicrobial Therapy for Severe Sepsis with No Obvious Source in Adults with Normal Renal Function
- 15. Acute Pulmonary Edema
- 16. Acute Respiratory Distress Syndrome
- 18. Confusion, Stupor, and Coma
- 19. Stroke
- 20. Subarachnoid Hemorrhage
  - 20. Subarachnoid Hemorrhage
  - T - 20-1. Grading Scales for Subarachnoid Hemorrhage
- 21. Increased Intracranial Pressure and Head Trauma
- 24. Status Epilepticus
  - 24. Status Epilepticus
  - F - 24-1. Pharmacologic Treatment of Generalized Tonic-Clonic Status Epilepticus (SE) in Adults
- 25. Diabetic Ketoacidosis and Hyperosmolar Coma
- 26. Hypoglycemia
- 27. Oncologic Emergencies
- 29. Bites, Venoms, Stings, and Marine Poisonings
- Section 2. Medical Emergencies
Section 3. Common Patient Presentations
Section 4. Otolaryngology
- 59. Sore Throat, Earache, and Upper Respiratory Symptoms
- Section 4. Otolaryngology
Section 5. Dermatology
- 60. General Examination of the Skin
- 61. Common Skin Conditions
- Section 5. Dermatology
Section 6. Hematology and Oncology
Section 7. Infectious Diseases
- 100. Mycoplasma pneumoniae, Legionella Species, and Chlamydia pneumoniae
  - 100. Mycoplasma pneumoniae, Legionella Species, and Chlamydia pneumoniae
  - Chlamydia Pneumoniae
  - Legionella Species
  - Mycoplasma Pneumoniae
- 101. Chlamydia trachomatis and Chlamydia psittaci
  - 101. Chlamydia trachomatis and Chlamydia psittaci
  - C. Psittaci Infections
  - C. Trachomatis Infections
- 102. Infections with Herpes Simplex Virus, Varicella-Zoster Virus, Cytomegalovirus, Epstein-Barr Virus, and Human Herpesvirus Types 6, 7, and 8
  - 102. Infections with Herpes Simplex Virus, Varicella-Zoster Virus, Cytomegalovirus, Epstein-Barr Virus, and Human Herpesvirus Types 6, 7, and 8
  - Cytomegalovirus
  - Epstein-Barr Virus
  - F - 102-1. Pattern of Epstein-Barr Virus (EBV) Serology During Acute Infection
  - Herpes Simplex Viruses
  - Human Herpesvirus (HHV) Types 6, 7, and 8
  - T - 102-1. Antiviral Chemotherapy for Herpes Simplex Virus (HSV) Infection
  - Varicella-Zoster Virus
- 103. Influenza and Other Viral Respiratory Diseases
  - 103. Influenza and Other Viral Respiratory Diseases
  - 104. Rubeola, Rubella, Mumps, and Parvovirus Infections
  - 105. Enterovirus Infections
  - Influenza
  - Other Common Viral Respiratory Infections
- 106. Insect- and Animal-Borne Viral Infections
  - 106. Insect- and Animal-Borne Viral Infections
  - F - 106-1. Algorithm for Rabies Postexposure Prophylaxis
- 107. HIV Infection and AIDS
  - 107. HIV Infection and AIDS
  - F - 107-1. Serologic Tests for the Diagnosis of HIV-1 or HIV-2 Infection
  - T - 107-1. Clinical Findings in the Acute HIV Syndrome
  - T - 107-2. Antiretroviral Drugs Most Commonly Used in the Treatment of HIV Infection
  - T - 107-2A. Combination Formulations of Antiretroviral Drugs
  - T - 107-3. Principles of Therapy of HIV Infection
  - T - 107-4. Initial Combination Regimens Recommended for Most Treatment-Nachr(239)ve Pts Regardless of HIV RNA Level or CD4 Count
  - T - 107-5. Indications for Changing Antiretroviral Therapy in Pts with HIV Infectiona
- 108. Pneumocystis Pneumonia, Candidiasis, and Other Fungal Infections
  - 108. Pneumocystis Pneumonia, Candidiasis, and Other Fungal Infections
  - T - 108-1. Treatment of Pneumocystosisa
  - T - 108-2. Prophylaxis of Pneumocystosis
  - T - 108-3. Treatment of Aspergillosisa
  - T - 108-4. Recommendations for the Diagnosis and Treatment of Histoplasmosis
- 109. Overview of Parasitic Infections
  - 109. Overview of Parasitic Infections
  - T - 109-1. Parasitic Infections, by Organ System and Signs/Symptoms
- 110. Malaria, Toxoplasmosis, Babesiosis, and Other Protozoal Infections
  - 110. Malaria, Toxoplasmosis, Babesiosis, and Other Protozoal Infections
  - Babesiosis
  - Leishmaniasis
  - Malaria
  - T - 110-1. Regimens for the Treatment of Malariaa
  - T - 110-2. Drugs Used in the Prophylaxis of Malaria
  - Toxoplasmosis
  - Trypanosomiasis
- 111. Helminthic Infections and Ectoparasite Infestations
  - 111. Helminthic Infections and Ectoparasite Infestations
  - Ectoparasites
  - Helminths
  - T - 111-1. Revised Diagnostic Criteria for Neurocysticercosisa
- 80. Growing Threats in Infectious Disease
  - 80. Growing Threats in Infectious Disease
  - T - 80-1. Antibiotic Resistance Threats in the United States, 2013
  - T - 80-2. The Most Common Mechanisms of Resistance to Antibacterial Agents
  - T - 80-3. Examples of Emerging and Reemerging Infectious Diseases
- 81. Infections Acquired in Health Care Facilities
  - 81. Infections Acquired in Health Care Facilities
  - T - 81-1. Examples of Selected Components of Evidence-Based Bundled Interventions to Prevent Common Health Care-Associated Infections and Other Adverse Eventsa
- 82. Infections in the Immunocompromised Host
  - 82. Infections in the Immunocompromised Host
  - F - 82-1. Algorithm for the Diagnosis and Treatment of Fever and Neutropenia
  - Immunizations In Immunosuppressed Pts
  - Infections In Cancer Pts
  - Infections In Transplant Recipients
  - T - 82-1. Disruption of Normal Barriers in Pts with Cancer That May Predispose Them to Infections
  - T - 82-2. Common Sources of Infection after Hematopoietic Stem Cell Transplantation
  - T - 82-3. Vaccination of Cancer and Transplant Pts Receiving Chemotherapya
- 83. Infective Endocarditis
  - 83. Infective Endocarditis
  - T - 83-1. The Modified Duke Criteria for the Clinical Diagnosis of Infective Endocarditisa
  - T - 83-2. Antibiotic Treatment for Infective Endocarditis Caused by Common Organismsa
  - T - 83-3. Timing of Cardiac Surgical Intervention in Pts with Endocarditis
  - T - 83-4. High-Risk Cardiac Lesions for Which Endocarditis Prophylaxis Is Advised before Dental Procedures
  - T - 83-5. Antibiotic Regimens for Prophylaxis of Endocarditis in Adults with High-Risk Cardiac Lesionsa,b
- 84. Intraabdominal Infections
  - 84. Intraabdominal Infections
  - F - 84-1. Algorithm for the Management of Pts with Intraabdominal Abscesses by Percutaneous Drainage
  - Intraabdominal Abscesses
  - Peritonitis
  - Visceral Abscesses
- 85. Infectious Diarrheas and Bacterial Food Poisoning
  - 85. Infectious Diarrheas and Bacterial Food Poisoning
  - F - 85-1. Clinical Algorithm for the Approach to Pts with Community-Acquired Infectious Diarrhea or Bacterial Food Poisoning
  - Inflammatory Diarrhea
  - Noninflammatory Diarrhea
  - T - 85-1. Gastrointestinal Pathogens Causing Acute Diarrhea
- 86. Sexually Transmitted and Reproductive Tract Infections
  - 86. Sexually Transmitted and Reproductive Tract Infections
  - General Principles
  - Individual Pathogens
  - Specific Syndromes
  - T - 86-1. Clinical Features of Genital Ulcers
  - T - 86-2. Recommended Treatment for Gonococcal Infections: Adapted from the 2015 Guidelines of the Centers for Disease Control and Prevention
  - T - 86-3. Recommendations for the Treatment of Syphilisa
- 87. Infections of the Skin, Soft Tissues, Joints, and Bones
  - 87. Infections of the Skin, Soft Tissues, Joints, and Bones
  - 88. Pneumococcal Infections
  - Infectious Arthritis
  - Osteomyelitis
  - Skin and Soft Tissue Infections
  - T - 87-1. Treatment of Common Infections of the Skin
  - T - 87-2. Antibiotic Therapy for Osteomyelitis in Adults Without Implantsa
- 89. Staphylococcal Infections
  - 89. Staphylococcal Infections
  - T - 89-1. Case Definition of Staphylococcus aureus Toxic Shock Syndrome
  - T - 89-2. Antimicrobial Therapy for Staphylococcal Infectionsa
- 90. Streptococcal/Enterococcal Infections, Diphtheria, and Infections Caused by Other Corynebacteria and Related Species
  - 90. Streptococcal/Enterococcal Infections, Diphtheria, and Infections Caused by Other Corynebacteria and Related Species
  - Corynebacterial and Related Infections
  - Streptococcal and Enterococcal Infections
  - T - 90-1. Treatment of Group A Streptococcal Infections
  - T - 90-2. Proposed Case Definition for the Streptococcal Toxic Shock Syndromea
- 91. Meningococcal and Listerial Infections
  - 91. Meningococcal and Listerial Infections
  - Listerial Infections
  - Meningococcal Infections
- 92. Infections Caused by Haemophilus, Bordetella, Moraxella, and HACEK Group Organisms
  - 92. Infections Caused by Haemophilus, Bordetella, Moraxella, and HACEK Group Organisms
  - Haemophilus Influenzae
  - Moraxella Catarrhalis
  - Pertussis
  - T - 92-1. Treatment of Infections Caused by HACEK Group
  - The Hacek Group
- 93. Diseases Caused by Gram-Negative Enteric Bacteria and Pseudomonads
  - 93. Diseases Caused by Gram-Negative Enteric Bacteria and Pseudomonads
  - Gram-Negative Enteric Bacteria
  - P. Aeruginosa and Related Organisms
  - T - 93-1. Antibiotic Treatment of Infections Due to Pseudomonas aeruginosa and Related Species
- 94. Infections Caused by Miscellaneous Gram-Negative Bacilli
  - 94. Infections Caused by Miscellaneous Gram-Negative Bacilli
  - Bartonella Infections
  - Brucellosis
  - Cat-Scratch Disease (CSD)
  - Plague
  - T - 94-1. Radiology of the Spine: Differentiation of Brucellosis from Tuberculosis
  - T - 94-2. Antimicrobial Therapy for Disease Caused by Bartonella Species in Adults
  - Tularemia
- 95. Anaerobic Infections
  - 95. Anaerobic Infections
  - Botulism
  - Definitions
  - Mixed Anaerobic Infections
  - Other Clostridial Infections
  - T - 95-1. Treatment of Clostridial Infections
  - T - 95-2. Antimicrobial Therapy That Is Typically Active Against Commonly Encountered Anaerobes
  - Tetanus
- 96. Nocardiosis, Actinomycosis, and Whipple's Disease
  - 96. Nocardiosis, Actinomycosis, and Whipple's Disease
  - Actinomycosis
  - Nocardiosis
  - T - 96-1. Treatment Duration for Nocardiosis
  - Whipple's Disease
- 97. Tuberculosis and Other Mycobacterial Infections
  - 97. Tuberculosis and Other Mycobacterial Infections
  - Infections With Nontuberculous Mycobacteria (NTM)
  - Leprosy
  - T - 97-1. Recommended Antituberculosis Treatment Regimens
  - T - 97-2. Tuberculin Reaction Size and Treatment of Latent Mycobacterium tuberculosis Infection
  - T - 97-3. Recommended Regimens and Drug Dosages for Treatment of Latent Mycobacterium tuberculosis Infectiona
  - Tuberculosis
- 98. Lyme Disease and Other Nonsyphilitic Spirochetal Infections
  - 98. Lyme Disease and Other Nonsyphilitic Spirochetal Infections
  - Endemic Treponematoses
  - Leptospirosis
  - Lyme Borreliosis
  - Relapsing Fever
- 99. Rickettsial Diseases
  - 99. Rickettsial Diseases
  - Ehrlichioses and Anaplasmosis
  - Flea- and Louse-Borne Typhus Group Rickettsioses
  - Q Fever
  - T - 99-1. Features of Selected Rickettsial Infections
  - Tick- and Mite-Borne Spotted Fevers
- Section 7. Infectious Diseases
Section 8. Cardiology
Section 9. Pulmonology
- 130. Diagnostic Procedures in Respiratory Disease
- 131. Asthma
- 132. Environmental Lung Diseases
- 133. Chronic Obstructive Pulmonary Disease
  - 133. Chronic Obstructive Pulmonary Disease
  - T - 133-1. GOLD Spirometric Grading Criteria for COPD Severity
- 134. Pneumonia, Bronchiectasis, and Lung Abscess
- 135. Pulmonary Thromboembolism and Deep-Vein Thrombosis
- 136. Interstitial Lung Disease
- 137. Diseases of the Pleura
- 139. Disorders of Ventilation
- Section 9. Pulmonology
Section 10. Nephrology
Section 11. Gastroenterology
Section 12. Allergy, Clinical Immunology, and Rheumatology
Section 13. Endocrinology and Metabolism
- 171. Disorders of the Anterior Pituitary and Hypothalamus
- 172. Diabetes Insipidus and Syndrome of Inappropriate Antidiuretic Hormone
  - 172. Diabetes Insipidus and Syndrome of Inappropriate Antidiuretic Hormone
  - T - 172-1. Causes of Syndrome of Inappropriate Antidiuretic Hormone (SIADH)
- 173. Thyroid Gland Disorders
- 174. Adrenal Gland Disorders
- 175. Obesity
  - 175. Obesity
  - F - 175-1. Bariatric Surgical Procedures
- 176. Diabetes Mellitus
- 177. Disorders of the Male Reproductive System
- 178. Disorders of the Female Reproductive System
- 179. Hypercalcemia and Hypocalcemia
- 180. Osteoporosis and Osteomalacia
- 181. Hypercholesterolemia and Hypertriglyceridemia
- 182. Hemochromatosis, Porphyrias, and Wilson's Disease
- Section 13. Endocrinology and Metabolism
Section 14. Neurology
Section 15. Psychiatry and Substance Abuse
- 199. Psychiatric Disorders
- 200. Psychiatric Medications
- 201. Eating Disorders
- 202. Alcohol Use Disorder
- 203. Narcotic Abuse
- 204. Cocaine and Other Commonly Used Drugs
- Section 15. Psychiatry and Substance Abuse
Section 16. Disease Prevention and Health Maintenance
- 205. Routine Disease Screening
- 206. Vaccines
  - 206. Vaccines
  - F - 206-1. Recommended Adult Immunization Schedules, United States, 2018
- 207. Cardiovascular Disease Prevention
- 208. Prevention and Early Detection of Cancer
- 209. Smoking Cessation
- 210. Women's Health
  - 210. Women's Health
  - Sex Differences In Health and Disease
- Section 16. Disease Prevention and Health Maintenance
Section 17. Adverse Drug Reactions
- 211. Adverse Drug Reactions
  - 211. Adverse Drug Reactions
  - T - 211-1. Clinical Manifestations of Adverse Reactions to Drugs
- Section 17. Adverse Drug Reactions
Front Matter

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Approach to Cytokeratin (CK7 and CK20) Markers Used in CUPS - Flowchart i

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Approach to Cytokeratin (CK7 and CK20) Markers Used in CUPS - Flowchart i