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The Johns Hopkins Manual of Gynecology and Obstetrics
Common Side Effects Of Chemotherapy, Targeted Therapy, and Hormonal Agents
Table of Contents
Free Topics
Abdominal Wall
About
Breast Cancer
Cell Cycle
Cervical Insufficiency
Differential Diagnosis Of Chronic Pelvic Pain
Epithelial Ovarian Tumors
Flowchart - Calculation and Dose Distribution for Initial Insulin Management in Pregnancy.
Flowchart - Thyroid Testing Algorithm.
Infections Of The Lower Female Genital Tract
Polycystic Ovary Syndrome
Preface
Preoperative Care
Risk Factors For Uterine Cancer
Part I : Obstetrics
1.Prepregnancy Counseling and Parental Care
Prepregnancy Care and Counseling
Routine Prenatal Care
Suggested Readings
10.Perinatal Infections
Bacterial Infections
Perinatal Infections
Protozoan Infections
Suggested Readings
Viral Infections
11.Multifetal Gestation
Antepartum Management
Delivery
Diagnosis
Fetal Complications
Maternal Complications
Multifetal Gestation
Selective Fetal Reduction
Suggested Readings
12.Fetal Therapy and In Utero Interventions
Exit Procedure
Fetoscopic Surgery
Introduction To Fetal Therapy
Open Fetal Surgery
Suggested Readings
Transplacental Therapy
Ultrasound-Guided Procedures
13.Hypertensive Disorders of Pregnancy
Chronic Hypertension
Definitions
Eclampsia
Gestational Hypertension
HELLP Syndrome
Magnesium Sulfate Management
Preeclampsia
Suggested Readings
14.Endocrine Disorders of Pregnancy
Adrenal Disorders
Diabetes Mellitus
Parathyroid Disorders
Pituitary Disorders
Suggested Readings
Thyroid Disorders
15.Cardiopulmonary Disorders of Pregnancy
Cardiac Disorders
Respiratory Disorders
Suggested Readings
16.Genitourinary Assessment and Renal Disease in Pregnancy
Acute Cystitis and Pyelonephritis
Acute Kidney Injury
Asymptomatic Bacteriuria
Chronic Kidney Disease
End-Stage Renal Disease and Renal Replacement Therapy
Kidney Transplant
Maternal Congenital Anomalies Of The Kidneys and Urinary Tract (Cakut)
Nephritic Syndrome
Nephrolithiasis
Nephrotic Syndrome
Suggested Readings
17.Gastrointestinal Disorders in Pregnancy
Acute Fatty Liver Of Pregnancy
Budd-chiari Syndrome (Bc Syndrome)
Cholelithiasis
Cirrhosis and Portal Hypertension
Effect Of Prior Bariatric Surgery
Gastroesophageal Reflux Disease
Inflammatory Bowel Disease
Intrahepatic Cholestasis Of Pregnancy
Nausea and Vomiting Of Pregnancy
Obesity
Peptic Ulcer Disease
Second-Line Antidiabetics In Pregnancy
Suggested Readings
18.Autoimmune Diseases in Pregnancy
Autoimmune Diseases in Pregnancy
Common Autoimmune Diseases
General Management Concerns
Immunomodulating Therapies In Pregnancy and Lactation
Multidisciplinary Care and Collaborative Approach
Suggested Readings
19.Neurologic Disorders in Pregnancy
Carpal Tunnel Syndrome
Chronic Neurologic Diseases
Headache
Neurologic Disorders in Pregnancy
Postpartum Compression Nerve Injuries
Suggested Readings
2.Maternal Physiology
Cardiovascular
Endocrine
Gastrointestinal
Hematologic
Immunologic
Maternal Physiology
Pulmonary
Renal
Reproductive Tract
Suggested Readings
20.Psychiatric Disease and Substance Use Disorder in the Pregnant and Postpartum Patient
Frequently Encountered Substances
Management
Management and Referral
Overall Approach To Peripartum Treatment Of Mental Health Conditions
Perinatal Substance Use Disorder
Peripartum Treatment Of Psychiatric Illness
Psychiatric Disease and Substance Use Disorder in the Pregnant and Postpartum Patient
Screening Tools For Emotional Changes In The Perinatal Patient
Suggested Readings
Taking A Mental Health History
Taking A Substance Use Disorder History
21.Hematologic Disorders and Thromboembolic Disease in Pregnancy
Maternal Hematologic Disorders
Suggested Readings
22.Neoplastic Diseases in Pregnancy
General Concepts
Neoplastic Diseases in Pregnancy
Suggested Readings
23.Skin Conditions in Pregnancy
Effect Of Pregnancy On Common Skin Conditions
Physiologic Skin Conditions Of Pregnancy
Pruritus Gravidarum (Idiopathic Pruritus)
Skin Conditions in Pregnancy
Suggested Readings
24.Surgical Disease and Trauma in Pregnancy
Cardiopulmonary Resuscitation In Pregnancy
Perioperative Considerations For Nonobstetric Surgery
Suggested Readings
Surgical Diseases In Pregnancy
Trauma In Pregnancy
25.Postpartum Care and Breastfeeding
Breastfeeding Recommendations
Routine Postpartum Care
Suggested Readings
26.Obstetric Emergencies
Breech Presentation
Hypertensive Crisis
Maternal Cardiopulmonary Arrest
Overview
Postpartum Hemorrhage
Shoulder Dystocia
Suggested Readings
3.Normal Labor and Delivery, Operative Delivery, and Malpresentations
Assisted Spontaneous Vaginal Delivery
Cesarean Section
Fetal Heart Rate Evaluation
Malpresentations
Management Of Normal Labor and Delivery
Mechanism Of Labor
Normal Labor and Delivery, Operative Delivery, and Malpresentations
Obstetric Lacerations
Operative Vaginal Delivery
Shoulder Dystocia
Stages and Phases Of Labor
Suggested Readings
Types Of Obstetric Analgesia/Anesthesia
Vaginal Birth After Cesarean Section
4.Complications of Labor and Delivery
Embolic Disease
Intra-Amniotic Infection
Postpartum Endomyometritis
Septic Pelvic Thrombophlebitis
Suggested Readings
Umbilical Cord Prolapse
Uterine Dehiscence Or Rupture
Uterine Inversion
5.Antepartum Fetal Assessment
Background
Confounding Factors In Fetal Assessment
Indications For Fetal Testing
Methods Of Fetal Assessment
Overall Surveillance Strategy
Suggested Readings
6.Congenital Anomalies
Chromosomal Abnormalities With Associated Congenital Anomalies
Common Specific Congenital Anomalies
Congenital Anomalies
Epidemiology
Etiology
Screening and Management
Suggested Readings
7.Parental Fetal Complications
Amniotic Fluid Disorders
Fetal Arrhythmias
Fetal Growth Restriction
Fetal Hematologic Disorders
Fetal Hydrops
Fetal Thrombocytopenia
Intrauterine Fetal Demise
Late-Term and Postterm Pregnancy
Oligohydramnios
Parental Fetal Complications
Suggested Readings
8.Preterm Labor, Cervical Insufficiency and Preterm Prelabor Rupture of Membranes
Cervical Insufficiency
Periviable Birth
Preterm Labor
Preterm Prelabor Rupture Of Membranes
Suggested Readings
9.Third-Trimester Bleeding and Placental Disorders
Placenta Accreta Spectrum
Placenta Previa
Placental Abruption
Suggested Readings
Third-Trimester Bleeding and Placental Disorders
Vasa Previa
Part II : General Gynecology
27.Primary and Preventive Care
Cancer Screening
Immunizations
Infectious Diseases
Metabolic, Endocrine, and Nutritional Conditions
Primary and Preventive Care
Screening For Heart and Vascular Conditions
Screening For Other Medical Conditions
Special Populations
Suggested Readings
28.Infections of the Genital Tract
Infections of the Genital Tract
Infections Of The Lower Female Genital Tract
Infections Of The Upper Genital Tract
Screening
Suggested Readings
29.Contraception and Sterilization
Barrier Methods
Contraception and Sterilization
Emergency (Postcoital) Contraception
Fertility Awareness-based Methods
Highly Effective Contraceptive Methods
Short-Acting Hormonal Contraceptive Methods
Suggested Readings
Tiers Of Effectiveness
30.Abortion
Abortion
Complications
Medication Abortion
Procedural Abortion
Suggested Readings
31.First and Second Trimester Pregnancy Loss and Ectopic Pregnancy
Assessment Of Pregnancy Location and Viability In The First Trimester
Early Pregnancy Loss In The First Trimester
Ectopic Pregnancy
First and Second Trimester Pregnancy Loss and Ectopic Pregnancy
Second Trimester Pregnancy Loss
Suggested Readings
32.Abnormal Uterine Bleeding
Abnormal Uterine Bleeding
Definition Of Abnormal Uterine Bleeding
Differential Diagnosis Of Abnormal Uterine Bleeding
Evaluation Of Abnormal Uterine Bleeding
Imaging Techniques and Tissue Sampling Methods
Management Of Abnormal Uterine Bleeding
Specific Causes Of Abnormal Uterine Bleeding
Suggested Readings
33.Chronic Pelvic Pain
Chronic Pelvic Pain
Definition
Differential Diagnosis Of Chronic Pelvic Pain
Evaluation Of Chronic Pelvic Pain
Key Considerations For Evaluating Chronic Pelvic Pain
Management Of Chronic Pelvic Pain
Suggested Readings
34.Uterine Leiomyomas and Benign Adnexal Masses
Adnexal Masses
Suggested Readings
Uterine Leiomyomas and Benign Adnexal Masses
Uterine Massesleiomyoma
35.Breast Diseases
Breast Cancer
Breast Diseases
Breast Exam
Common Breast Disorders and Complaints
Special Considerations In Breast Disease
Suggested Readings
36.Benign Vulvar Disorders
Anatomy Of The Vulva
Approach To Diagnosing Vulvar Disease
Benign Vulvar Cysts
Benign Vulvar Disorders
Painful Vulvar Lesions
Pruritic Vulvar Lesions
Suggested Readings
Vulvar Pain Syndromes
37.Female Sexual Function and Alterations in Sexual Functioning
Alterations In Functioning: Assessment
Alterations In Functioning: Diagnosis
Domains Of Sexuality
Epidemiology
Establishing Concepts Of Sexual Health and Wellness
Female Sexual Function and Alterations in Sexual Functioning
Physiology Of Sexual Function
Screening For Sexual Wellness and Function
Special Considerations and Populations
Suggested Readings
Theories Of Sexual Function
Treatments
38.LGBTQ and Transgender Care
Barriers To Health Care and Discrimination
Gender Transition
Gynecologic and Obstetrical Care Of Gender and Sexual Minority Patients
Overview and Definitions
Suggested Readings
39.Pediatric Gynecology
Common Pediatric Gynecology Complaints
Congenital Anomalies Of The Female Reproductive Tract
Disorders Of Puberty
Gynecologic Evaluation Of A Prepubertal Child
Gynecologic Evaluation Of An Adolescent
Pediatric Gynecology
Suggested Readings
Part III : Reproductive Endocrinology and Infertility
40.The Menstrual Cycle
Menstrual Cycle Overview
Phases Of The Menstrual Cycle
Suggested Readings
The Menstrual Cycle
41.Infertility and Assisted Reproductive Technologies
Complications Of Assisted Reproductive Technologies
Etiologies
Infertility
Infertility Evaluation
Oocyte Retrieval, Culture, Fertilization, and Transfer
Suggested Readings
Third-Party Reproduction
Treatment For Infertility
Treatments Beyond Ovulation Induction With Timed Intercourse
42.Fertility Preservation
Endometriosis
Fertility Preservation
Fertility Preservation For Patients Receiving Gonadotoxic Treatment Or Gonadectomy
Planned Fertility Preservation
Suggested Readings
Transgender Males/Gender Diverse Individuals
43.Recurrent Pregnancy Loss
Epidemiology and Definition
Etiologies
Evaluation
Suggested Readings
Treatment Principles
44.Menstrual Disorders: Endometriosis, Dysmenorrhea, and Premenstrual Dysphoric Disorder
Adenomyosis
Dysmenorrhea
Endometriosis
Premenstrual Disorder: Premenstrual Dysphoria and Premenstrual Dysphoric Disorder
Suggested Readings
45.Amenorrhea
Amenorrhea
Differential Diagnosis
Etiologies Of Amenorrheasystematic Evaluation
Evaluation
Suggested Readings
46.Polycystic Ovary Syndrome and Hyperandrogenism
Androgen-Producing Ovarian Or Adrenal Tumors
Androgens In The Female
Causes Of Hyperandrogenism
Definition and Androgen Physiology
Diagnosis Of Hyperandrogenism
Hyperandrogenism In Postmenopausal Patients
Idiopathic and Drug-Induced Hirsutism
Nonclassical (Late-Onset) Congenital Adrenal Hyperplasia
Polycystic Ovary Syndrome
Signs and Symptoms Of Hyperandrogenism
Suggested Readings
47.Menopause
Cancer Screening While On Mht
Definitions and Epidemiology Of Menopause
Physiology Of Menopause
Special Concerns For Menopausal Patients
Suggested Readings
Symptoms
Part IV : Female Pelvic Medicine and Reconstructive Surgery
48.Urinary Incontinence and Lower Urinary Tract Symptoms
Etiology and Risk Factors
Impact On Health
Patient Evaluation
Suggested Readings
Treatment
Types Of Urinary Incontinence and Lower Urinary Tract Symptoms
Urinary Incontinence and Lower Urinary Tract Symptoms
Urinary Retention
49.Pelvic Organ Prolapse
Epidemiology
Pelvic Organ Prolapse
Pelvic Organ Prolapse Signs and Symptoms
Recommended Evaluation For Patients With Suspected Prolapse
Risk Factors
Suggested Readings
Treatment Of Pop
50.Anal Incontinence
Anal Incontinence
Etiology
Patient Evaluation
Suggested Readings
Treatment
Part V : Gynecologic Oncology
51.Premalignant Disease of the Cervix, Vagina, and Vulva
Cin 1
Cin 2/3
Diagnostic Categories Via Colposcopy: Histology
Diagnostic Categories: Cytology
Epidemiology Of Cervical Neoplasia
Management Strategies: Cytologic Abnormalities
Management Strategies: Histologic Abnormalities
Management Strategies: Hrhpv Positive On Primary Screening
Primary Prevention
Screening Guidelines
Screening Methods
Suggested Readings
Treatment Of Vain and Vin
Vaginal Intraepithelial Neoplasia
Vulvar Intraepithelial Neoplasia
52.Cervical, Vulvar, and Vaginal Cancer
Cervical Cancer
Suggested Readings
Vaginal Cancer
Vulvar Cancer
53.Uterine Cancer
Classification
Epidemiology
Management Of Uterine Cancer
Presentation, Evaluation, and Diagnosis
Protective Factors and Prevention
Racial Disparities In Endometrial Cancer
Risk Factors For Uterine Cancer
Screening
Staging and Prognosis
Suggested Readings
Surveillance
Uterine Sarcomas
54.Ovarian Cancer
Epidemiology Of Ovarian Cancer
Epithelial Ovarian Tumors
Germ Cell Ovarian Tumors
Ovarian Cancer
Ovarian Metastases From Other Sites Of Origin
Sex Cord-stromal Ovarian Tumors
Suggested Readings
55.Gestational Trophoblastic Disease
Gestational Trophoblastic Disease
Gestational Trophoblastic Disease
Gestational Trophoblastic Neoplasia
Suggested Readings
Types Of Trophoblastic Cells
56.Chemotherapy, Targeted Therapy, and Radiation Therapy
Cell Cycle
Chemotherapy, Targeted Therapy, and Hormonal Agents
Chemotherapy, Targeted Therapy, and Radiation Therapy
Common Side Effects Of Chemotherapy, Targeted Therapy, and Hormonal Agents
Radiation Therapy
Suggested Readings
Part VI : General Topics in Obstetrics and Gynecology
57.Disparities in Obstetric and Gynecologic Outcomes
Benign Hysterectomy
Cancer
Cesarean Delivery
Gestational Diabetes
Implicit Bias
Introduction
Maternal Mortality
Oasis Tears
Postpartum Hemorrhage
Preterm Birth
Severe Maternal Morbidity
Suggested Readings
What Are Health Disparities?
58.Anatomy of the Female Pelvis
Abdominal Wall
Autonomic Nerves Of The Pelvis
Endopelvic Fascia
Lymphatic Drainage Of The True Pelvis/Viscera
Pelvic Floor, Vulva, and Perineum
Pelvic Viscera
Somatic Nerves Of The Pelvis
Suggested Readings
Surgical Spaces Of The Retroperitoneum
Vasculature Of The Pelvis
59.Surgical Approaches in Gynecology
Hysteroscopy
Laparoscopy
Laparotomy
Suggested Readings
Surgical Approaches in Gynecology
Vaginal
60.Perioperative Care and Complications of Gynecologic Surgery
Intraoperative Complications
Postoperative Complications
Preoperative Care
Suggested Readings
61.Critical Care
Cardiovascular Critical Care
Critical Care
Fluids and Electrolytes
Hematologic Critical Care
Infectious Disease
Renal Failure
Respiratory Critical Care
Special Obstetric Considerations In Critical Care
Suggested Readings
62.Quality, Safety, and Value in Obgyn Care
Clinical Innovation In Quality, Safety, and Value
Examples Of Quality Improvement Initiatives
Measuring Quality In Health Care
Quality Improvement Tools
Quality, Safety, and Value in Obgyn Care
Risk Reduction and Safety Tools
Safety
Suggested Readings
The Role Of Artificial Intelligence In Obgyn
Value
Front Matter
Preface
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