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TNM Cancer Staging System
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N1a is defined as metastasis in one regional lymph node
N1b is described as one lymph node metastasis 5 mm or greater
N1 is defined as involvement of regional lymph nodes
N2a is defined as metastasis in 4 to 6 regional lymph nodes
N2b is described as two or more lymph node metastases 5 mm or greater
N2c is described as lymph node(s) with extranodal extension
N3 is described as fixed or ulcerated regional lymph node metastasis
N1a is described as one or two lymph nodes metastasis each less than 5 mm
N1 disease is defined as a single or multiple regional lymph node involvement
N1 is pelvic or inguinal lymph node metastasis
N2a is described as three or more lymph node metastases each less than 5 mm
N2b showing nodal masses in more than 7 regional lymph nodes
N2 is defined as in-transit metastasis (discontinuous from primary tumor; located between primary tumor and draining regional nodal basin, or distal to the primary tumor) without lymph node metastasis
Natural history of GIST
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