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Stoelting's Handbook of Pharmacology and Physiology in Anesthetic Practice
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Insulin
Insulin Stimulates Tissue Uptake of Glucose and Amino Acids, Whereas Release of Fatty Acids is Inhibited
Pancreas
Proinsulin, Which is Converted to Insulin by Proteolytic Cleavage of Amino Acids 31, 32, 64, 65, and the Connecting Peptide
Regulation of Insulin Secretion
replacement therapy for
replacement therapy for|pharmacokinetics of
replacement therapy for|preparations and delivery of
replacement therapy for|side effects of
resistance to
Intercompartmental clearance
Interstitial fluid
Introduction
pressure of
pressure of|colloid osmotic
space
Intervening cleft
Intracellular fluid
Intracellular pH regulation
Intracellular Functions Affected by Local pH
Mechanisms for Regulation of Hydrogen Ion Concentration
Intracranial pressure (ICP)
Central Nervous System
GABA agonists and
opioids and
succinylcholine and
with inhaled anesthetics
Intragastric pressure, succinylcholine and
Intraocular pressure (IOP)
GABA agonists and
succinylcholine and
Intravenous anesthetics, airway and
Anesthetics with a Favorable Influence on Bronchomotor Tone
Influence of Anesthetics on the Airways
Intravenous fluids
colloids
colloids|albumin
colloids|semisynthetic
constituents of|calcium
constituents of|copper
constituents of|iron
constituents of|magnesium
constituents of|phosphate
constituents of|potassium
constituents of|zinc
crystalloids
fluid responsiveness
Intravenous regional anesthesia (Bier block)
Clinical Uses of Local Anesthetics
Uses of Local Anesthetics
Intravenous sedation
benzodiazepines for
GABA agonists for
Overview
Intrinsic-PEEP
Inverse agonists
Receptor Theory
The Simple View of Receptor Activation Also Explains the Action of Antagonist
Iodine
Iodophors
Ion channels
Cell Structure and Function
Diameters of Ions, Molecules, and Channels
How Nerves Work
ligand-gated
voltage-gated
Ionization
Characteristics of Nonionized and Ionized Drug Molecules
Ionization
Ions
diameters of
plasma concentration of
Ion trapping
Iron
deficiency of
in intravenous fluids
Ischemic heart disease
Ischemic optic neuropathy (ION)
Ischemic reflex of CNS
Isotonic solutions
chr(206)chr(178)-Adrenergic receptor antagonists
Antiarrhythmic Drug Pharmacology
Beta-Adrenergic receptor antagonists
Comparative Characteristics of ß-Adrenergic Receptor Antagonists Effective in the Treatment of Congestive Heart Failure
for airway|inhaled
for airway|systemic
Heparin Administration is Associated With Decreased Plasma Protein Binding of Propranolol Manifesting As an Increased Plasma Concentration of Free (Unbound) Drug
hyperkalemia with
chr(206)±- combined with
Intravenous Antihypertensive Drugs Commonly Used in the Perioperative Setting
Maximum Percent Increases in Heart Rate (HR) and Systolic Blood Pressure (SBP) after Induction of Anesthesia and Direct Laryngoscopy With Tracheal Intubation in Patients Pretreated With Saline, Lidocaine, Fentanyl, or Esmolol
Possible Explanations for Cardioprotective Effects Produced by Perioperative ß-Adrenergic Receptor Blockade
Systemic Hypertension is Estimated to Affect 30% of Adults in the United States and is Defined As 150 to 159/90 to 99 Mm Hg (Stage 1) or Greater Than or Equal to 160/100 Mm Hg (Stage 2)
chr(206)chr(178)-Adrenergic receptors
classification of
drugs that act on
How Nerves Work
Schematic Diagram Showing G Protein-Coupled Receptors, the ß2-Adrenergic Receptor, Which Upregulates Adenylyl Cyclase, and the M2 Muscarinic Receptor, Which Downregulates Adenylyl Cyclase (AC)
chr(206)chr(178) waves
Central Nervous System
The Electroencephalogram Consists of Alpha, Beta, Theta, and Delta Waves
chr(206)chr(179)-Aminobutyric acid (GABA) agonists
clinical uses of
commercial preparations of
mechanism of action
metabolism of
nonhypnotic therapeutic applications of
Overview
pharmacokinetics of
side effects of
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