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TNM Cancer Staging Manual
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Table of Contents
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Adrenal Neuroendocrine Tumors
Anus
Calculator - Adrenal Cortical Carcinoma(Clinical) - TNM Calc
Calculator - Adrenal Cortical Carcinoma(Pathological) - TNM Calc
Cervical Lymph Nodes and Unknown Primary Tumors of the Head and Neck
Colon and Rectum
Conjunctival Carcinoma
Esophagus and Esophagogastric Junction: Adenocarcinoma
Esophagus and Esophagogastric Junction: Other Histologies
Esophagus and Esophagogastric Junction: Squamous Cell Carcinoma
Exocrine Pancreas
Introduction and Overview
Kidney
Leukemia: Acute Myeloid Leukemia
Lip and Oral Cavity
Liver
Lung
Mucosal Melanoma of the Head and Neck
Nasopharynx
Neuroendocrine Tumors of the Pancreas
Perihilar Bile Ducts
Stomach
Vulva
Part I: General Information on Cancer Staging and End-Results Reporting
1. Principles of Cancer Staging
1. Principles of Cancer Staging
Additional Staging Descriptors and Guidelines
AJCC Prognostic Stage Groups
AJCC TNM Staging System: Classifications, Categories and Rules for Staging
General Staging Rules
Introduction and Overview
Stage Classifications
2. Organization of the AJCC Cancer Staging Manual
2. Organization of the AJCC Cancer Staging Manual
Cancer Staging Data Form
Developing the 8th Edition Project Plan
New for This Edition
Organization of AJCC Cancer Staging Content
Vision for the AJCC Cancer Staging Manual, 8th Edition
3. Cancer Survival Analysis
3. Cancer Survival Analysis
Basic Concepts
Bibliography
Cause-Adjusted Survival
Comparison of Survival between Patient Groups
Competing Risks/Cumulative Incidence
Introduction
Patient-, Disease-, and Treatment-Specific Survival
Relative Survival
Stand ard Error of a Survival Estimate
Summary
The Kaplan-Meier Method
The Life Table Method
4. Risk Models for Individualized Prognosis in the Practice of Precision Oncology
4. Risk Models for Individualized Prognosis in the Practice of Precision Oncology
Acknowledgments
Background
Bibliography
Considerations for Use of Prognostication Models
Endorsement of Prognostication Models Meeting AJCC Criteria
Establishing Endorsement Criteria for Prognostication Models
Search Strategy for Prognostication Tools
The Evaluation Process
Part II: Head and Neck
5. Staging Head and Neck Cancers
10. HPV-Mediated (p16+) Oropharyngeal Cancer
11-A. Oropharynx (p16-)
11-B. Hypopharynx
12. Nasal Cavity and Ethmoid Sinus
13-A. Larynx: Supraglottis
13-B. Larynx: Glottis
13-C. Larynx: Subglottis
13-D. Larynx: Not Otherwise Specified
14. Mucosal Melanoma of the Head and Neck
15. Cutaneous Carcinoma of the Head and Neck
5. Staging Head and Neck Cancers
6. Cervical Lymph Nodes and Unknown Primary Tumors of the Head and Neck
7-A. Lip and Oral Cavity
7-B. Oral Cavity
8. Major Salivary Gland s
9. Nasopharynx
Bibliography
Collection of Key Patient and Tumor Factors
Distant Metastases
Introduction and Overview of Key Concepts
Key Changes to Head and Neck Cancer Staging
Principles of Staging
Regional Lymph Nodes
Survival Data
Part III: Upper Gastrointestinal Tract
16-A. Esophagus and Esophagogastric Junction: Squamous Cell Carcinoma
16-B. Esophagus and Esophagogastric Junction: Adenocarcinoma
16-C. Esophagus and Esophagogastric Junction: Other Histologies
17. Stomach
18-A. Small Intestine: Adenocarcinoma
18-B. Small Intestine: Other Histologies
Part IV: Lower Gastrointestinal Tract
19. Appendix: Carcinoma
20. Colon and Rectum
21. Anus
Part V: Hepatobiliary System
22. Liver
23. Intrahepatic Bile Ducts
24. Gallbladder
25. Perihilar Bile Ducts
26. Distal Bile Duct
27. Ampulla of Vater
28. Exocrine Pancreas
Part VI: Neuroendocrine Tumors
29. Neuroendocrine Tumors of the Stomach
30. Neuroendocrine Tumors of the Duodenum and Ampulla of Vater
31. Neuroendocrine Tumors of the Jejunum and Ileum
32. Neuroendocrine Tumors of the Appendix
33. Neuroendocrine Tumors of the Colon and Rectum
34. Neuroendocrine Tumors of the Pancreas
Part VII: Thorax
35. Thymus
36. Lung
37. Malignant Pleural Mesothelioma
Part VIII: Bone
38-A. Bone: Appendicular Skeleton, Trunk, Skull and Facial Bones
38-B. Bone: Spine
38-C. Bone: Pelvis
Part IX: Soft Tissue Sarcoma
39. Introduction to Soft Tissue Sarcoma
40. Soft Tissue Sarcoma of the Head and Neck
41. Soft Tissue Sarcoma of the Trunk and Extremities
42. Soft Tissue Sarcoma of the Abdomen and Thoracic Visceral Organs
43-A. Gastrointestinal Stromal Tumor: Gastric and Omental
43-B. Gastrointestinal Stromal Tumor: Small Intestinal, Esophageal, Colorectal, Mesenteric, and Peritoneal
44. Soft Tissue Sarcoma of the Retroperitoneum
45. Soft Tissue Sarcoma Unusual Histologies and Sites
Part X: Skin
46. Merkel Cell Carcinoma
47. Melanoma of the Skin
Part XI: Breast
48-A. Breast
48-A. Breast: Ductal Carcinoma in situ
Part XII: Female Reproductive Organs
49. Introduction to Female Reproductive Organs
49. Introduction to Female Reproductive Organs
50. Vulva
51. Vagina
52. Cervix Uteri
53. Corpus Uteri: Carcinoma and Carcinosarcoma
54. Corpus Uteri: Adenosarcoma
54. Corpus Uteri: Leiomyosarcoma and Endometrial Stromal Sarcoma
55. Ovary, Fallopian Tube, and Primary Peritoneal Carcinoma
56. Gestational Trophoblastic Neoplasms
Introduction
Part XIII: Male Genital Organs
57. Penis
Part XIV: Urinary Tract
58. Kidney
59. Renal Pelvis and Ureter: Squamous Cell Carcinoma and Adenocarcinoma
59. Renal Pelvis and Ureter: Urothelial Carcinomas
60. Urinary Bladder: Squamous Cell Carcinoma and Adenocarcinoma
60. Urinary Bladder: Urothelial Carcinomas
61. Male Penile and Female Urethra: Squamous Cell Carcinoma and Adenocarcinoma
61. Male Penile and Female Urethra: Urothelial Carcinomas
61. Prostatic Urethra: Squamous Cell Carcinoma and Adenocarcinoma
61. Prostatic Urethra: Urothelial Carcinomas
Part XV: Ophthalmic Sites
62. Eyelid Carcinoma
63. Conjunctival Carcinoma
64. Conjunctival Melanoma
65. Uvea: Choroidal and Ciliary Body Melanomas
65. Uvea: Iris Melanomas
66. Retinoblastoma
67. Lacrimal Gland Carcinoma
68. Orbital Sarcoma
69. Ocular Adnexal Lymphoma
Part XVI: Central Nervous System
70. Brain and Spinal Cord
Part XVII: Endocrine System
71. Thyroid: Anaplastic
71. Thyroid: Differentiated
72. Thyroid: Medullary
73. Parathyroid
74. Adrenal Cortical Carcinoma
75. Adrenal Neuroendocrine Tumors
Part XVIII: Hematologic Malignancies
76. Introduction to Hematologic Malignancies
77. Hodgkin Lymphoma
77. Non-Hodgkin Lymphoma: Chronic Lymphocytic Leukemia Small Lymphocytic Lymphoma
77. Non-Hodgkin Lymphoma: Diffuse Large B-Cell Lymphoma
77. Non-Hodgkin Lymphoma: Follicular Lymphoma
77. Non-Hodgkin Lymphoma: Mantle Cell Lymphoma
77. Non-Hodgkin Lymphoma: Marginal Zone Lymphoma
77. Non-Hodgkin Lymphoma: Not Otherwise Specified
77. Non-Hodgkin Lymphoma: Peripheral T-Cell Lymphoma
78. Pediatric Hodgkin Lymphomas
78. Pediatric Non-Hodgkin Lymphomas
79. Primary Cutaneous Lymphomas: Mycosis Fungoides and Sezary Syndrome
80. Other Plasma Cell Disorders
80. Plasma Cell Myeloma
81. Leukemia: Acute Lymphoblastic Leukemia in Children
81. Leukemia: Acute Lymphocytic Leukemia in Adults
81. Leukemia: Acute Myeloid Leukemia
81. Leukemia: Chronic Myeloid
81. Leukemia: Unspecified or Other Type
Bibliography
Introduction
Pathology
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