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The Maudsley Prescribing Guidelines in Psychiatry
Prescribing drugs outside their licensed indications (‘off-label' prescribing)
Table of Contents
Free Topics
About
Alcohol dependence
Biochemical and haematological effects of psychotropics
Contributors' conflict of interest
Covert administration of medicines within food and drink
Dementia
Depression in older adults
Drug interactions with alcohol
Flowchart - Algorithm for treating catatonic stupor.
Flowchart - Flow chart for the use of covert medication.
General principles in prescribing in older adults
List of abbreviations
Preface
Stimulant use disorder (SUD)
Tics and Tourette's syndrome in children and adolescents
Treatment of acute mania or hypomania
1. Schizophrenia and Related Psychoses
Acutely disturbed or violent behaviour
Akathisia
Alternative routes of administration
Alternatives to clozapine
Antipsychotic depots/long-acting injections
Antipsychotic prophylaxis
Antipsychotic response - to increase the dose, to switch, to add or just wait - what is the right move?
Antipsychotic-associated hyponatraemia
Antipsychotic-induced weight gain
Antipsychotics - minimum effective doses
Aripiprazole long-acting injection
Blood pressure changes with antipsychotics
Catatonia
Clozapine and chemotherapy
Clozapine initiation schedules
Clozapine, neutropenia and lithium
Clozapine: common adverse effects
Clozapine: serious cardiovascular adverse effects
Clozapine: serious haematological adverse effects
Clozapine: uncommon or unusual adverse effects
Clozapine-induced gastrointestinal hypomotility
Clozapine-induced hypersalivation
Combined antipsychotics (antipsychotic polypharmacy)
Depot antipsychotics - summary of pharmacokinetics
Diabetes and impaired glucose tolerance
ECG changes - QT prolongation
Effects of antipsychotic medications on plasma lipids
Electroconvulsive therapy and psychosis
Equivalent doses
Extrapyramidal symptoms
First-generation antipsychotics - place in therapy
General introduction
General principles of prescribing
Genetic testing for clozapine treatment
High-dose antipsychotic medication: prescribing and monitoring
Hyperprolactinaemia
Initiation of clozapine in the community
Intramuscular clozapine
Management of patients on long-term treatment with long-acting injectable antipsychotic medication
Monitoring
Negative symptoms
Neuroleptic malignant syndrome
NICE guidelines for the treatment of schizophrenia
Olanzapine long-acting injection
Omega-3 fatty acid (fish oils) in schizophrenia
Optimising clozapine treatment
Paliperidone palmitate long-acting injection
Penfluridol weekly
Pneumonia
Quick reference for licensed maximum doses
Relative adverse effects - a rough guide
Restarting clozapine after a break in treatment
Risperidone long-acting injection
Sexual dysfunction and antipsychotics
Stopping antipsychotics
Switching antipsychotics
Treatment algorithms for schizophrenia
Treatment of antipsychotic-induced weight gain
Treatment of tardive dyskinesia
Venous thromboembolism
2. Bipolar Disorder
Antipsychotic drugs in bipolar disorder
Antipsychotic long-acting injections in bipolar disorder
Bipolar depression
Carbamazepine
Lithium
Physical monitoring for people with bipolar disorder,
Prophylaxis in bipolar disorder
Rapid-cycling bipolar affective disorder
Stopping lithium and mood stabilisers
Treatment of acute mania or hypomania
Valproate
3. Depression and Anxiety Disorders
Antidepressant prophylaxis
Antidepressant withdrawal symptoms
Antidepressant-induced arrhythmia
Antidepressant-induced hyponatraemia
Antidepressants - general overview
Antidepressants and diabetes mellitus
Antidepressants and hyperprolactinaemia
Antidepressants and sexual dysfunction
Antidepressants: relative adverse effects - a rough guide
Anxiety spectrum disorders
Benzodiazepines and disinhibition
Benzodiazepines in the treatment of psychiatric disorders
Benzodiazepines, z-drugs and gabapentinoids: dependence, withdrawal effects and discontinuation
Cardiac effects of antidepressants - summary
Drug interactions with antidepressants
Drug treatment of depression
Electroconvulsive therapy and psychotropic drugs
Introduction to depression
Ketamine
Management of treatment-resistant depression - commonly used treatments
Management of treatment-resistant depression - other well supported treatments
Official guidance on the treatment of depression
Post-stroke depression
Premenstrual syndrome
Psychostimulants in depression
Psychotic depression
Recognised minimum effective doses of antidepressants
Signs and symptoms
SSRIs and bleeding
St John's wort
Stopping antidepressants
Switching antidepressants
Treatment-resistant depression - other reported treatments
4. Addictions and Substance Misuse
Alcohol dependence
Benzodiazepine misuse
Drug-induced excited state
Drugs of misuse - a summary
Gambling disorder
GHB and GBL dependence
Interactions between illicit drugs and prescribed psychotropic drugs
Introduction
Nicotine and smoking cessation
Opioid dependence
Stimulant use disorder (SUD)
Substance misuse in pregnancy
5. Prescribing in Children and Adolescents
Anxiety disorders in children and adolescents
Attention deficit hyperactivity disorder (ADHD) in children and adolescents
Autism spectrum disorder (ASD) in children and adolescents
Bipolar disorder in children and adolescents
Depression in children and adolescents
Doses of commonly used psychotropic drugs in children and adolescents
Melatonin in the treatment of insomnia in children and adolescents
Obsessive compulsive disorder (OCD) and body dysmorphic disorder (BDD) in children and adolescents
Post-traumatic stress disorder (PTSD) in children and adolescents
Principles of prescribing practice in childhood and adolescence
Psychosis in children and adolescents
Rapid tranquillisation (RT) in children and adolescents
Tics and Tourette's syndrome in children and adolescents
6. Prescribing in Older People
A guide to medication doses of commonly used psychotropics in older adults, [1] /National Institute for Health and Care Excellence (NICE).
Covert administration of medicines within food and drink
Dementia
Depression in older adults
General principles in prescribing in older adults
Management of behavioural and psychological symptoms of dementia (BPSD)
Management of inappropriate sexual behaviour in older adults
Safer prescribing for physical conditions in dementia
7. Prescribing in Pregnancy and Breastfeeding
Drug choice in breastfeeding
Drug choice in pregnancy
8. Prescribing in Hepatic and Renal Impairment
Hepatic impairment
Renal impairment
9. Drug Treatment of Other Psychiatric Conditions
Attention deficit hyperactivity disorder (ADHD) in adults
Borderline personality disorder (BPD)
Eating disorders
10. Drug Treatment of Psychiatric Symptoms Occurring in the Context of Other Conditions
22q11.2 deletion syndrome
Atrial fibrillation
Bariatric surgery
Epilepsy
Huntington's disease
Learning disabilities
Menopause
Multiple sclerosis
Parkinson's disease
Prescribing in human immunodeficiency virus (HIV)
11. Pharmacokinetics
Acting on clozapine plasma concentration results
Drug interactions with alcohol
Interpreting postmortem blood concentrations
Plasma level monitoring of psychotropic drugs
Psychotropic drugs and cytochrome (CYP) function
Smoking and psychotropic drugs
12. Other Substances
Caffeine
Nicotine
13. Psychotropic Drugs in Special Conditions
Driving and psychotropic medicines
Psychotropics in overdose
14. Prescribing Psychotropics
Prescribing drugs outside their licensed indications (‘off-label' prescribing)
Relational aspects of prescribing practice
Restarting psychotropic medications after a period of non-compliance
Site of administration of intramuscular injections
The Mental Health Act in England and Wales
Working towards adherence
15. Miscellany
Biochemical and haematological effects of psychotropics
Summary of psychiatric adverse effects of non-psychotropics
Front Matter
Contributors' conflict of interest
List of abbreviations
Preface
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