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N1a is defined as metastasis in one regional lymph node
N1b is described as one lymph node metastasis 5 mm or greater
N1 is defined as involvement of regional lymph nodes
N1 is pelvic or inguinal lymph node metastasis
N2a is described as three or more lymph node metastases each less than 5 mm
N2b showing nodal masses in more than 7 regional lymph nodes
N2 is defined as in-transit metastasis (discontinuous from primary tumor; located between primary tumor and draining regional nodal basin, or distal to the primary tumor) without lymph node metastasis
N3 is described as fixed or ulcerated regional lymph node metastasis
Neuroendocrine tumors of the small bowel: Kaplan-Meier survival curves by the 8th Edition proposed clinical stage, with a follow-up time of 3 years (2010-2013) and adjusted for patient age
Neuroendocrine tumors of the small bowel: Kaplan-Meier survival curves with 95% confidence intervals by 8th Edition pathological Stage II, n = 281/3366 Data from the National Cancer Data Base (diagnosis years 2010-2013), adjusted for patient age
N1a is described as one or two lymph nodes metastasis each less than 5 mm
N1 disease is defined as a single or multiple regional lymph node involvement
N1 is defined as metastasis to one to three regional lymph nodes (tumor in lymph node measuring greater than or equal to 0
N2a is defined as metastasis in 4 to 6 regional lymph nodes
N2b is described as two or more lymph node metastases 5 mm or greater
N2c is described as lymph node(s) with extranodal extension
N2 is defined as metastasis in 4 or more regional lymph nodes
Natural history of GIST
Neuroendocrine tumors of the small bowel: Kaplan-Meier survival curves with 95% confidence intervals by 8th Edition pathological Stage I, n = 142/3366 Data from the National Cancer Data Base (diagnosis years 2010-2013), adjusted for patient age
Neuroendocrine tumors of the small bowel: Kaplan-Meier survival curves with 95% confidence intervals by 8th Edition pathological Stage III, n =2,136/3366
Neuroendocrine tumors of the small bowel: Kaplan-Meier survival curves with 95% confidence intervals by the 8th Edition proposed clinical Stage I, n =269/1855
Neuroendocrine tumors of the small bowel: Kaplan-Meier survival curves with 95% confidence intervals by the 8th Edition proposed clinical Stage III, n =617/1855
Neuroendocrine tumors of the small bowel: Kaplan-Meier survival curves with 95% confidence intervals by 8th Edition pathological Stage IV, n =807/3366
Neuroendocrine tumors of the small bowel: Kaplan-Meier survival curves with 95% confidence intervals by the 8th Edition proposed clinical Stage II, n =240/1855
Neuroendocrine tumors of the small bowel: Kaplan-Meier survival curves with 95% confidence intervals by the 8th Edition proposed clinical Stage IV, n =729/1855

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