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Cancer Pharmacology: An Illustrated Manual of Anticancer Drugs
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all-trans retinoic acid (ATRA)
Answer 8.2
Question 8.1
Differentiating Agents and Microenvironment
American Society of Clinical Oncology (ASCO)
AML
anaplastic lymphoma kinase (ALK)
Targeted Therapies (Small Molecules)
Anaplastic Lymphoma Kinase (ALK) Fusion
and rogen deprivation therapy (ADT)
Male Hormonal Therapies
Question 10.2
Overview of Prostate Cancer (PC) Progression and Treatment
and rogen receptor (AR)
Molecular Mechanism of and rogen Receptor (AR) Activation by Dihydrotestosterone (DHT)
Male Hormonal Therapies
Physiological and Anatomical Targets of FDA-Approved "Hormonal" Drugs for Prostate Cancer
and rogen response element (ARE)
antibody-dependent cell-mediated cytotoxicity (ADCC)
Naked Monoclonal Antibody Mechanism of Action
Components of 90y-Ibritumomab Tiuxetan
Novel Therapeutic Strategies in Oncology
antibody-dependent cellular cytotoxicity (ADCC)
antibody-drug conjugates (ADC)
Monoclonal Antibodies Including Immunoconjugates and Cytokine-Directed Agents
Multiple Myeloma as a Paradigm for Multi-Targeted Intervention
Anticancer drug development
limitations to effective action
pathophysiology of cancer
targets
usefulness
work at all, stop working, or never work?
overview
pharmacokinetics
treatment goal
usefulness|Kaplan-meier method, survival in the two groups
Antifolates
action mechanism
folate transporters
absorption and elimination
adverse events
overview
toxicity and rescue
relative affinities of folate receptor (FR) and reduced folate carrier (RFC)
toxicity and rescue|leucovorin (LV) "rescue" in high-dose MTX
toxicity and rescue|THF compared to leucovorin (folinic acid, LV) structure
treatment goal
toxicity and rescue|MTX breakdown via glucarpidase
toxicity and rescue|urinary excretion of high-dose MTX and effect of medications and urine pH
ALT
aminotransferase (AST)
ANC
antibody-dependent cellular phagocytosis (ADCP)
Antimetabolites
classification
treatment goal
overview
Antimitotics
chromosome cycle
ixabepilone
microtubules
treatment goal
adverse events related to vinca alkaloids
eribulin
microtubule-directed agents
taxanes, adverse events
vinca alkaloids and neurotoxicity
Antivascular endothelial growth factor
APL
Apoptosis
therapeutic activation
BH3 mimetics
a proliferation-inducing ligand (APRIL)
ara-C
ara-CMP
ARDS
area under the plasma drug concentration-time curve (AUC)
Pharmacokinetics: Relation to Toxicity or Achievement of Steady State
Transplant-Related Agents
aromatase inhibitors (AIs)
arsenic trioxide (ATO)
Differentiating Agents and Microenvironment
Answer 8.2
Question 8.2
ASCO
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