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For appendicular skeleton, trunk, skull, and facial bones, T2 is defined as tumor more than 8 cm in greatest dimension
For appendicular skeleton, trunk, skull, and facial bones, T3 is defined as discontinuous tumors in the primary bone site
For carcinomas T1a is tumor limited to the endometrium or invading less than half the myometrium
For carcinomas T1b is tumor invading one half or more of the myometrium
For carcinomas T2 is tumor invading the stromal connective tissue of the cervix but not extending beyond the uterus
For carcinomas T3a is tumor involving the serosa and /or adnexa (direct extension or metastasis)
For carcinomas T4 is tumor invading the bladder mucosa and /or bowel mucosa (bullous edema is not sufficient to classify a tumor as T4)
For colon or rectum N1 is defined as regional lymph node metastasis
For colon or rectum T1b is defined as tumor that is size 1-2 cm in greatest dimension
For colon or rectum T1 is defined as tumor that invades the lamina propria or submucosa and size 2 cm or less
For colon or rectum T2 is defined as tumor that invades the muscularis propria (left side) or size more than 2 cm with invasion of the lamina propria or submucosa (right side)
For colon or rectum T3 is defined as tumor that invades through the muscularis propria into the subserosa (left side), or into non-peritonealized pericolic or perirectal tissues (right side)
For colon or rectum T4 is defined as tumor that invades the peritoneum or other organs
For duodenum T1 is defined as tumor that invades lamina propria (left side) or submucosa (right side) and size 1 cm or less
For duodenum T2 is defined as tumor that invades muscularis propria or size greater than 1 cm
For stomach T4 is defined as tumor that invades visceral peritoneum (serosa) or other organs or adjacent structures
Histologic appearance of major extranodal extension (ENE)
HR-HPV-mediated oropharyngeal cancer can form cystic metastases in cervical lymph nodes, whereas the primary carcinoma is usually solid
Impact of positive nodes, the total number of nodes examined, and the depth of primary tumor invasion in a population-based cohort of colon carcinoma
Impact of positive nodes, the total number of nodes examined, and the depth of primary tumor invasion in a population-based cohort of rectal carcinoma
Impact of tumor location relative to hepatic and peritoneal surfaces, by T category
International Association for the Study of Lung Cancer lymph node map (From Rusch et al
In the context of oropharyngeal cancer, the optimal cut-off for p16 overexpression as a surrogate HR HPV biomarker is greater than or equal to +2/+3 nuclear staining intensity (+/- cytoplasmic staining) with greater than or equal to 75% distribution
In the context of oropharyngeal cancer, these histologies are predictive of HR-HPV-mediated carcinogenesis and p16 overexpression
In the female, T3 is defined as tumor that invades the anterior vagina
In the female, T4 is defined as tumor that invades other adjacent organs (illustrated is invasion of the pubic bone and vulva)
In the male, T2 is defined as tumor with invasion of the corpus spongiosum
In the male, T3 is defined as tumor with invasion of the corpus cavernosum (left) or the prostatic capsule (right)
In the nasal cavity and ethmoid sinus, T1 is defined as tumor restricted to any one subsite, with or without bony invasion
Invasion of urethra and bladder tumors into prostratic stroma