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Cancer Pharmacology: An Illustrated Manual of Anticancer Drugs
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AKI
alanine aminotransferase (ALT)
alanine transaminase (ALT)
aldehyde dehydrogenase (ALDH)
ALDH
ALK
Alkylating agents
cyclophosphamide and ifosfamide
ethylenimines
methylguanine methyltransferase, clinical importance
nitrosoureas
platinum compounds
treatment goal
triazines (three attached nitrogen atoms)
ALL
allo-hematopoietic stem cell transplantation (HSCT)
Answer 15.3
Answer 15.4
Answer 15.5
Mechanism of Action of High-Dose Cyclophosphamide Graft-Versus-Host Disease (GVHD) Prophylaxis
Question 15.1
Question 15.2
Question 15.3
Question 15.4
Transplant-Related Agents
all-trans retinoic acid (ATRA)
Answer 8.2
Differentiating Agents and Microenvironment
Question 8.1
α-ketoglutarate (α-KG)
α-KG
ALT
American Society of Clinical Oncology (ASCO)
aminotransferase (AST)
AML
anaplastic lymphoma kinase (ALK)
Anaplastic Lymphoma Kinase (ALK) Fusion
Targeted Therapies (Small Molecules)
ANC
and rogen deprivation therapy (ADT)
Male Hormonal Therapies
Overview of Prostate Cancer (PC) Progression and Treatment
Question 10.2
and rogen receptor (AR)
Male Hormonal Therapies
Molecular Mechanism of and rogen Receptor (AR) Activation by Dihydrotestosterone (DHT)
Physiological and Anatomical Targets of FDA-Approved "Hormonal" Drugs for Prostate Cancer
and rogen response element (ARE)
antibody-dependent cell-mediated cytotoxicity (ADCC)
Components of 90y-Ibritumomab Tiuxetan
Naked Monoclonal Antibody Mechanism of Action
Novel Therapeutic Strategies in Oncology
antibody-dependent cellular cytotoxicity (ADCC)
antibody-dependent cellular phagocytosis (ADCP)
antibody-drug conjugates (ADC)
Monoclonal Antibodies Including Immunoconjugates and Cytokine-Directed Agents
Multiple Myeloma as a Paradigm for Multi-Targeted Intervention
Anticancer drug development
limitations to effective action
overview
pathophysiology of cancer
pharmacokinetics
targets
treatment goal
usefulness
usefulness|Kaplan-meier method, survival in the two groups
work at all, stop working, or never work?
Antifolates
absorption and elimination
action mechanism
adverse events
folate transporters
overview
relative affinities of folate receptor (FR) and reduced folate carrier (RFC)
toxicity and rescue
toxicity and rescue|leucovorin (LV) "rescue" in high-dose MTX
toxicity and rescue|MTX breakdown via glucarpidase
toxicity and rescue|THF compared to leucovorin (folinic acid, LV) structure
toxicity and rescue|urinary excretion of high-dose MTX and effect of medications and urine pH
treatment goal
antigen-presenting cells (APCs)
Antimetabolites
classification
overview
treatment goal
Antimitotics
adverse events related to vinca alkaloids
chromosome cycle
eribulin
ixabepilone
microtubule-directed agents
microtubules
taxanes, adverse events
treatment goal
vinca alkaloids and neurotoxicity
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