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T3a is tumor involves lower third of vagina but not extending to the pelvic wall
T3b: Tumor extends into vena cava below the diaphragm
T3b melanoma
T3c includes extension of tumor to capsule of liver and spleen without parenchymal involvement of either organ
T3 for the supraglottis is defined as tumor limited to larynx with vocal cord fixation and /or invading any of the following: postcricoid area, preepiglottic tissues, paraglottic space, and /or inner cortex of thyroid cartilage (shown here with invasion of the supraglottis and vocal cord with vocal cord fixation)
T3 includes separate tumor nodule(s) in the same lobe as the primary
T3 is defined as mucosal disease
T3 is defined as tumor larger than 4 cm in greatest dimension
T3 is defined as tumor that invades the subserosa, shown here invading the lesser omentum without involvement of the serosa (visceral peritoneum)
T3 is defined as tumor through the muscularis propria into subserosal tissue without penetration of overlying serosa
T3 is described as tumor of any size with extension to any of the following: upper/promixal two-thirds of urethra, upper/proximal two-thirds of vagina, bladder mucosa, rectal mucosa, or fixed to pelvic bone
T3 is tumor extending to the pelvic sidewall and /or involving the lower third of the vagina and /or causing hydronephrosis or nonfunctioning kidney
T3 tumor of the hypopharynx with fixation of the hemilarynx and invasion of the pyriform sinus, aryepiglottic fold, and posterior wall
T3 tumors of the glottis are limited to the larynx with vocal cord fixation (shown), and /or invade paraglottic space and /or inner cortex of the thyroid cartilage
T3 tumors of the subglottis are limited to the larynx with vocal cord fixation
T4: Invasion into ipsilateral adrenal gland
T4a for the supraglottis is defined as moderately advanced local disease, tumor invading through the thyroid cartilage and /or invading tissues beyond the larynx (e
T4a is defined as gross extrathyroidal extension invading subcutaneous soft tissues, larynx, trachea, esophagus, or recurrent laryngeal nerve from a tumor of any size
T4a is defined as moderately advanced disease; tumor of any size with gross extrathyroidal extension into the nearby tissues of the neck, including subcutaneous soft tissue, larynx, trachea, esophagus, or recurrent laryngeal nerve
T4a is defined as tumor that invades through the visceral peritoneum, including the acellular mucin or mucinous epithelium involving the serosa of the appendix or serosa of the mesoappendix
T4a is defined as tumor that penetrates the serosa (visceral peritoneum) without invasion of adjacent structures, whereas T4b is defined as tumor that radially invades adjacent structures, shown here invading the pancreas
T4a tumor of the hypopharynx that is moderately advanced local disease, with invasion of the hyoid bone, thyroid/cricoid cartilage, thyroid gland , or central compartment soft tissue
T4a tumors of the glottis are moderately advanced local disease, and invade through the outer cortex of the thyroid cartilage and /or invade tissues beyond the larynx (e
T4b is defined as gross extrathyroidal extension invading prevertebral fascia or encasing the carotid artery or mediastinal vessels from a tumor of any size
T4b is defined as very advanced disease, with tumor involving the brain as illustrated, or also involving dura, lower cranial nerves (IX, X, XI, XII), masticator space, carotid artery, prevertebral space, or mediastinal structures
T4b is defined as very advanced local disease, tumor involves masticator space, pterygoid plates (as shown), or skull base and /or encases internal carotid artery
T4b tumor of the oropharynx is a tumor described as very advanced local disease, a tumor that invades lateral pterygoid muscle, pterygoid plates, lateral nasopharynx, or skull base or encases carotid artery
T4 for leiomyosarcoma, endometrial stromal sarcoma, and adenosarcoma is tumor invades bladder or rectum
T4 is defined as tumor greater than 7 cm or tumor of any size invading one or more of the following: diaphragm, mediastinum, heart, great vessels, trachea, recurrent laryngeal nerve, esophagus, vertebral body, or carina; separate tumor nodule(s) in an ipsilateral lobe different from that of the primary
T2 is tumor extends to other genital structures (ovary, tube, vagina, broad ligaments) by metastasis or direct extension
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