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T3 is defined as tumor greater than 5 cm but less than or equal to 7 cm in greatest dimension or directly invading any of the following: parietal pleura (PL3), chest wall (including superior sulcus tumors), phrenic nerve, parietal pericardium; or separate tumor nodule(s) in the same lobe as the primary
T3 is defined as tumor of any size with local invasion but not invading adjacent organs
T3 is defined as tumor that invades through the muscularis propria into the subserosa or the mesoappendix
T3 is defined as tumor with a maximum clinical diameter 5 cm
T3 is locally advanced but potentially resectable tumor
T3 tumor of the hypopharynx larger than 4 cm in diameter and with involvement of the posterior wall
T3 tumor of the hypopharynx with fixation of the hemilarynx with invasion of the pyriform sinus and post-cricoid area
T3 tumors of the oropharynx are larger than 4 cm in greatest dimension or have extension to lingual surface of epiglottis
T4: Invasion beyond Gerota's fascia
T4a (Lip) is defined as moderately advanced local disease, tumor invading through cortical bone, inferior alveolar nerve, floor of mouth, or skin of face, i
T4a in the nasal cavity and ethmoid sinus is moderately advanced local disease, and invades any of the following: anterior orbital contents, skin of nose or cheek, minimal extension to anterior cranial fossa, pterygoid plates, sphenoid, or frontal sinuses
T4a is defined as moderately advanced disease, with tumor involving deep soft tissue, cartilage, bone, or overlying skin
T4a is defined as moderately advanced local disease, tumor invading adjacent structures only (e
T4a is defined as tumor that penetrates the serosa (visceral peritoneum) without invasion of adjacent structures
T4a melanoma
T4a tumor of the oropharynx is described as moderately advanced local disease, a tumor that invades the larynx, extrinsic muscle or tongue, medial pterygoid, hard palate, or mand ible
T4a tumors of the subglottis are moderately advanced local disease, and invade cricoid or thyroid cartilage and /or invade tissues beyond the larynx (e
T4b is defined as tumor that directly invades or adheres to adjacent organs or structures
T4b is defined as very advanced disease; tumor of any size with extension toward the spine or into nearby large blood vessels, invading the prevertebral fascia, or encasing the carotid artery or mediastinal vessels
T4b melanoma
T4b tumor the hypopharynx that is very advanced local disease, with invasion of the prevertebral fascia, encases carotid artery, or involves mediastinal structures
T4 is defined as a primary tumor invading fascia, muscle, cartilage, or bone
T4 is defined as tumor of any size that invades adjacent organs (kidney, diaphragm, pancreas, spleen, or liver) or large blood vessels (renal vein or vena cava)
T4 is defined as tumor that invades other adjacent organs (invasion of the bladder is illustrated)
T4 is tumor invading mucosa of bladder or rectum, and /or extends beyond true pelvis (bullous edema is not sufficient to classify a tumor as T4)
T4 tumor with prostatic invasion
Ta is defined as noninvasive localized squamous cell carcinoma
The anatomic subsites of the bone
The regional lymph nodes of the appendix
The regional lymph nodes of the duodenum

NDX