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T3 is defined as tumor greater than 5 cm but less than or equal to 7 cm in greatest dimension or directly invading any of the following: parietal pleura (PL3), chest wall (including superior sulcus tumors), phrenic nerve, parietal pericardium; or separate tumor nodule(s) in the same lobe as the primary
T3 is defined as tumor of any size with local invasion but not invading adjacent organs
T3 is defined as tumor that invades through the muscularis propria into the subserosa or the mesoappendix
T3 is defined as tumor with a maximum clinical diameter 5 cm
T3 is locally advanced but potentially resectable tumor
T3 tumor of the hypopharynx larger than 4 cm in diameter and with involvement of the posterior wall
T3 tumor of the hypopharynx with fixation of the hemilarynx with invasion of the pyriform sinus and post-cricoid area
T3 tumors of the oropharynx are larger than 4 cm in greatest dimension or have extension to lingual surface of epiglottis
T4: Invasion beyond Gerota's fascia
T4a (Lip) is defined as moderately advanced local disease, tumor invading through cortical bone, inferior alveolar nerve, floor of mouth, or skin of face, i
T4a in the nasal cavity and ethmoid sinus is moderately advanced local disease, and invades any of the following: anterior orbital contents, skin of nose or cheek, minimal extension to anterior cranial fossa, pterygoid plates, sphenoid, or frontal sinuses
T4a is defined as moderately advanced disease, with tumor involving deep soft tissue, cartilage, bone, or overlying skin
T4a is defined as moderately advanced local disease, tumor invading adjacent structures only (e
T4a is defined as moderately advanced disease; tumor of any size with gross extrathyroidal extension into the nearby tissues of the neck, including subcutaneous soft tissue, larynx, trachea, esophagus, or recurrent laryngeal nerve
T4a is defined as tumor that invades through the visceral peritoneum, including the acellular mucin or mucinous epithelium involving the serosa of the appendix or serosa of the mesoappendix
T4a is defined as tumor that penetrates the serosa (visceral peritoneum) without invasion of adjacent structures, whereas T4b is defined as tumor that radially invades adjacent structures, shown here invading the pancreas
T4a tumor of the hypopharynx that is moderately advanced local disease, with invasion of the hyoid bone, thyroid/cricoid cartilage, thyroid gland , or central compartment soft tissue
T4a tumors of the glottis are moderately advanced local disease, and invade through the outer cortex of the thyroid cartilage and /or invade tissues beyond the larynx (e
T4b is defined as gross extrathyroidal extension invading prevertebral fascia or encasing the carotid artery or mediastinal vessels from a tumor of any size
T4b is defined as very advanced disease, with tumor involving the brain as illustrated, or also involving dura, lower cranial nerves (IX, X, XI, XII), masticator space, carotid artery, prevertebral space, or mediastinal structures
T4b is defined as very advanced local disease, tumor involves masticator space, pterygoid plates (as shown), or skull base and /or encases internal carotid artery
T4b tumor of the oropharynx is a tumor described as very advanced local disease, a tumor that invades lateral pterygoid muscle, pterygoid plates, lateral nasopharynx, or skull base or encases carotid artery
T4 for leiomyosarcoma, endometrial stromal sarcoma, and adenosarcoma is tumor invades bladder or rectum
T4 is defined as tumor greater than 7 cm or tumor of any size invading one or more of the following: diaphragm, mediastinum, heart, great vessels, trachea, recurrent laryngeal nerve, esophagus, vertebral body, or carina; separate tumor nodule(s) in an ipsilateral lobe different from that of the primary
T4 is defined as tumor that invades into adjacent structures such as scrotum, prostate, pubic bone (shown here)
T4 is locally advanced, technically unresectable tumor
T4 is tumor invading the mucosa of the bladder or rectum and /or extending beyond the true pelvis (bullous edema is not sufficient evidence to classify a tumor as T4)
T4 tumor with scrotal invasion
The anal canal extends from the proximal aspect of the external sphincter to the anal verge at the intersphincteric groove
The Ophthalmic Oncology Task Force (OOTF) Multicenter International Survey collected data required to stage eye(s) with retinoblastoma by five different schemes