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T4 for leiomyosarcoma, endometrial stromal sarcoma, and adenosarcoma is tumor invades bladder or rectum
T4 is defined as tumor greater than 7 cm or tumor of any size invading one or more of the following: diaphragm, mediastinum, heart, great vessels, trachea, recurrent laryngeal nerve, esophagus, vertebral body, or carina; separate tumor nodule(s) in an ipsilateral lobe different from that of the primary
T4 is defined as tumor that invades into adjacent structures such as scrotum, prostate, pubic bone (shown here)
T4 is locally advanced, technically unresectable tumor
T4 is tumor invading the mucosa of the bladder or rectum and /or extending beyond the true pelvis (bullous edema is not sufficient evidence to classify a tumor as T4)
T4 tumor with scrotal invasion
The anal canal extends from the proximal aspect of the external sphincter to the anal verge at the intersphincteric groove
The Ophthalmic Oncology Task Force (OOTF) Multicenter International Survey collected data required to stage eye(s) with retinoblastoma by five different schemes
The regional lymph nodes of the colon and rectum
The regional lymph nodes of the ileum and jejunum
The regional lymph nodes of the small intestine for neuroendocrine tumors
The regional lymph nodes of the ureter
T4 is defined as a primary tumor invading fascia, muscle, cartilage, or bone
T4 is defined as tumor of any size that invades adjacent organs (kidney, diaphragm, pancreas, spleen, or liver) or large blood vessels (renal vein or vena cava)
T4 is defined as tumor that invades other adjacent organs (invasion of the bladder is illustrated)
T4 is tumor invading mucosa of bladder or rectum, and /or extends beyond true pelvis (bullous edema is not sufficient to classify a tumor as T4)
T4 tumor with prostatic invasion
Ta is defined as noninvasive localized squamous cell carcinoma
The anatomic subsites of the bone
The regional lymph nodes of the appendix
The regional lymph nodes of the duodenum
The regional lymph nodes of the renal pelvis
The regional lymph nodes of the stomach for neuroendocrine tumors
The retroperitoneal pancreatic margin (hatched area; also referred to as the mesenteric or uncinated margin) consists of soft tissue that often contains perineural tissue adjacent to the superior mesenteric artery
Top: A “strand y” pattern with intervening skeletal muscle observable at low-power is often classifiable as WPOI-5
Two views of T3: on the left, tumor more than 4 cm in greatest dimension limited to the thyroid (categorized as T3a); on the right, a tumor of any size with gross extrathyroidal extension invading only strap muscles (sternohyoid, sternothyroid, thyrohyoid or omohyoid muscles) (categorized as T3b)
Two views of T4b in the nasal cavity and ethmoid sinus
These nodal metastases are considered M1
Tumors of the head of the pancreas are those arising to the right of the superior mesenteric-portal vein confluence
Two views of T3 in the nasal cavity and ethmoid sinus showing tumor invading maxillary sinus and palate (left) and extending to the floor of the orbit (right)

NDX